Imaging changes associated with cognitive abnormalities in Parkinson’s disease
Identifieur interne : 000A42 ( Main/Exploration ); précédent : 000A41; suivant : 000A43Imaging changes associated with cognitive abnormalities in Parkinson’s disease
Auteurs : Yuko Koshimori ; Barbara Segura ; Leigh Christopher ; Nancy Lobaugh ; Sarah Duff-Canning ; Romina Mizrahi ; Clement Hamani ; Anthony E. Lang ; Kelly Aminian ; Sylvain Houle ; Antonio P. StrafellaSource :
- Brain structure & function [ 1863-2653 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Cerebral Cortex (pathology), Cognition Disorders (complications), Cognition Disorders (pathology), Diffusion Tensor Imaging, Executive Function, Female, Gray Matter (pathology), Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (pathology), Psychiatric Status Rating Scales, White Matter (pathology).
- MESH :
- complications : Cognition Disorders, Parkinson Disease.
- pathology : Cerebral Cortex, Cognition Disorders, Gray Matter, Parkinson Disease, White Matter.
- Aged, Analysis of Variance, Diffusion Tensor Imaging, Executive Function, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales.
Abstract
The current study investigates both gray and white matter changes in non-demented Parkinson’s disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.
Url:
DOI: 10.1007/s00429-014-0785-x
PubMed: 24816399
PubMed Central: 4485490
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000756
- to stream Pmc, to step Curation: 000756
- to stream Pmc, to step Checkpoint: 000472
- to stream PubMed, to step Corpus: 000467
- to stream PubMed, to step Curation: 000467
- to stream PubMed, to step Checkpoint: 000467
- to stream Ncbi, to step Merge: 001757
- to stream Ncbi, to step Curation: 001757
- to stream Ncbi, to step Checkpoint: 001757
- to stream Main, to step Merge: 000A45
- to stream Main, to step Curation: 000A42
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Imaging changes associated with cognitive abnormalities in Parkinson’s disease</title><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name></author><author><name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name></author><author><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name></author><author><name sortKey="Lobaugh, Nancy" sort="Lobaugh, Nancy" uniqKey="Lobaugh N" first="Nancy" last="Lobaugh">Nancy Lobaugh</name></author><author><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name></author><author><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name></author><author><name sortKey="Aminian, Kelly" sort="Aminian, Kelly" uniqKey="Aminian K" first="Kelly" last="Aminian">Kelly Aminian</name></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24816399</idno><idno type="pmc">4485490</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485490</idno><idno type="RBID">PMC:4485490</idno><idno type="doi">10.1007/s00429-014-0785-x</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000756</idno><idno type="wicri:Area/Pmc/Curation">000756</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000756</idno><idno type="wicri:Area/Pmc/Checkpoint">000472</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000472</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000467</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000467</idno><idno type="wicri:Area/PubMed/Curation">000467</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000467</idno><idno type="wicri:Area/PubMed/Checkpoint">000467</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000467</idno><idno type="wicri:Area/Ncbi/Merge">001757</idno><idno type="wicri:Area/Ncbi/Curation">001757</idno><idno type="wicri:Area/Ncbi/Checkpoint">001757</idno><idno type="wicri:doubleKey">1863-2653:2014:Koshimori Y:imaging:changes:associated</idno><idno type="wicri:Area/Main/Merge">000A45</idno><idno type="wicri:Area/Main/Curation">000A42</idno><idno type="wicri:Area/Main/Exploration">000A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Imaging changes associated with cognitive abnormalities in Parkinson’s disease</title><author><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name></author><author><name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name></author><author><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name></author><author><name sortKey="Lobaugh, Nancy" sort="Lobaugh, Nancy" uniqKey="Lobaugh N" first="Nancy" last="Lobaugh">Nancy Lobaugh</name></author><author><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name></author><author><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name></author><author><name sortKey="Aminian, Kelly" sort="Aminian, Kelly" uniqKey="Aminian K" first="Kelly" last="Aminian">Kelly Aminian</name></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name></author><author><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></author></analytic><series><title level="j">Brain structure & function</title><idno type="ISSN">1863-2653</idno><idno type="eISSN">1863-2661</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Cerebral Cortex (pathology)</term><term>Cognition Disorders (complications)</term><term>Cognition Disorders (pathology)</term><term>Diffusion Tensor Imaging</term><term>Executive Function</term><term>Female</term><term>Gray Matter (pathology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Psychiatric Status Rating Scales</term><term>White Matter (pathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term><term>Cognition Disorders</term><term>Gray Matter</term><term>Parkinson Disease</term><term>White Matter</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Diffusion Tensor Imaging</term><term>Executive Function</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychiatric Status Rating Scales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The current study investigates both gray and white matter changes in non-demented Parkinson’s disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aminian, Kelly" sort="Aminian, Kelly" uniqKey="Aminian K" first="Kelly" last="Aminian">Kelly Aminian</name><name sortKey="Christopher, Leigh" sort="Christopher, Leigh" uniqKey="Christopher L" first="Leigh" last="Christopher">Leigh Christopher</name><name sortKey="Duff Canning, Sarah" sort="Duff Canning, Sarah" uniqKey="Duff Canning S" first="Sarah" last="Duff-Canning">Sarah Duff-Canning</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Koshimori, Yuko" sort="Koshimori, Yuko" uniqKey="Koshimori Y" first="Yuko" last="Koshimori">Yuko Koshimori</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lobaugh, Nancy" sort="Lobaugh, Nancy" uniqKey="Lobaugh N" first="Nancy" last="Lobaugh">Nancy Lobaugh</name><name sortKey="Mizrahi, Romina" sort="Mizrahi, Romina" uniqKey="Mizrahi R" first="Romina" last="Mizrahi">Romina Mizrahi</name><name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Barbara" last="Segura">Barbara Segura</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A42 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A42 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4485490
|texte= Imaging changes associated with cognitive abnormalities in Parkinson’s disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24816399" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |